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| 白果内酯抑制持续性脑栓塞大鼠水通道蛋白1，4及胶质纤维酸性蛋白的表达 | |
| 引用本文： | 秦海明,曲红,宋福林,游松,翟兴文,韩红光,秦斌. 白果内酯抑制持续性脑栓塞大鼠水通道蛋白1，4及胶质纤维酸性蛋白的表达[J]. 中国神经再生研究, 2011, 6(27) |
| 作者姓名： | 秦海明 曲红 宋福林 游松 翟兴文 韩红光 秦斌 |
| 作者单位： | School of Life Science and Biopharmaceutic,沈阳军区总医院，病理科,沈阳军区总医院，病理科,沈阳药科大学，生命科学与生物制药学院,沈阳药科大学，生命科学与生物制药学院,沈阳军区总医院，病理科,沈阳药科大学，生命科学与生物制药学院 |
| 基金项目： | a Research Subject of General Hospital of Shenyang Military Area Command of Chinese PLA* |
| 摘 要： | 实验结果发现白果内酯预处理可以降低永久性大脑中动脉闭塞大鼠脑组织含水量和梗死面积；下调水通道蛋白1，4 mRNA在水肿脑组织中的表达，继而抑制其合成，特别是在缺血的早期阶段（8 h）；抑制胶质纤维酸性蛋白的表达，减轻反应性胶质增生。说明白果内酯可通过抑制水通道蛋白的表达减轻脑水肿。 |
| 关 键 词： | 白果内酯；水通道蛋白；脑水肿；永久性大脑中动脉闭塞；GFAP；神经再生 |
Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia |
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| Haiming Qin,,Fulin Song,Hongguang Han,Hong Qu,Xingwen Zhai,Bin Qin,Song You School of Life Science , Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang ,Liaoning Province,China. Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia[J]. Neural Regeneration Research, 2011, 6(27) | |
| Authors: | Haiming Qin Fulin Song Hongguang Han Hong Qu Xingwen Zhai Bin Qin Song You School of Life Science Biopharmaceutics Shenyang Pharmaceutical University Shenyang Liaoning Province China |
| Affiliation: | Haiming Qin1,2,Fulin Song2,Hongguang Han2,Hong Qu2,Xingwen Zhai1,Bin Qin1,Song You1 1School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,Liaoning Province,China 2Department of Pathology,General Hospital of Shenyang Military Area Command of Chinese PLA,China |
| Abstract: | The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins. |
| Keywords: | bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration |
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