多普勒血流灌注指数和超声造影诊断结直肠癌肝转移

目的评价超声多普勒血流灌注指数（DPI）及CEUS检测结直肠癌（CRC）肝转移灶的价值。方法 15例CRC术后具有明显肝转移灶的患者和15名健康志愿者接受超声检查,并计算DPI。对其中9例患者的9个病灶进行CEUS检查,测量其开始增强时间,峰值时间和开始消退时间。结果 15例CRC肝转移患者的DPI较健康志愿者明显升高（0.41±0.12vs 0.20±0.06,P〈0.05）;CEUS示9个转移灶均可见门脉相的快速廓清和实质相的充盈缺损,表现为＂快进快出＂的特点。结论 DPI是一种检测CRC肝脏转移的敏感方法,联合应用CEUS有助于发现更多的肝转移灶。

Doppler perfusion index and contrast-enhanced ultrasound in diagnosis of liver metastases from colorectal cancer

Objective To assess the value of the Doppler perfusion index (DPI) and contrast-enhanced ultrasound (CEUS) in the detection of liver metastases in patients with colorectal cancer (CRC). Methods DPI was measured in 15 patients with CRC metastases and 15 control subjects. Then 9 patients with 9 liver metastases underwent CEUS. The beginning time of enhancement, the time of peak enhancement and the beginning time of washout were recorded. Results DPI of patients with CRC liver metastases was significantly higher than that of control subjects (0.41±0.12 vs 0.20±0.06, P<0.05). All 9 liver metastasis showed rapid washout of contrast agent during the portal venous phase, followed by complete washout during the parenchymal phase, and were differentiated as "fast wash-in and fast wash-out" contrast enhancement patter. Conlusion DPI is a sensitive technique in the detection of liver metastases from CRC. More liver metastasis would be detected by DPI combined with CEUS.