VEGF-C、IGF-1R在胰腺癌中的表达及其临床意义

【目的】探讨胰腺癌组织中VEGF-C、IGF-1R的表达及其意义。【方法】应用免疫组织化学SP法分别检测34例胰腺癌组织和10例正常胰腺组织中VEGF-c及IGF-1R的表达。对其表达情况及其与临床病理特征、预后的关系进行分析。【结果】分析表明：①VEGF-C、IGF-1R在胰腺癌组织中阳性表达率分别为61．76％、55．88％，均高于在正常胰腺组织中的表达（20％和10％）（P〈0．05，）。②胰腺癌组织中，有淋巴结转移者的VEGF-C、IGF-1R阳性表达（79．16％和70．83％）明显高于无淋巴结转移者（均为20％）（P〈0．05），VEGF-C与IGF-1R在（UICC）Ⅲ、IV期中阳性表达要高于I、Ⅱ期（P〈0．05）。③VEGF-C表达与IGF-1R表达呈正相关（P〈O．05）。④Kaplan-Meier法分析显示VEGF-C、IGF-1R表达阳性者的生存时间较阴性者短。【结论】胰腺癌组织中VEGF-C和IGF-1R表达增强且呈正相关，两者联合检测可推断患者有无淋巴结转移，对患者病情和预后的判断是有帮助的。

Expression of VEGF-C and IGF-1R in Pancreatic Carcinoma and Its Clinical Significance

[Objective]To investigate the expression of VEGF-C and IGF-1R in pancreatic carcinoma and its clinical significance. [Methods] Immunohistoehemistry （SP method） method was used to detect the expression of VEGF-C and IGF-1R in 34 cases of human pancreatic carcinoma and 10 cases of normal pancreatic tissue. The results were analyzed, and the clinicopathological characteristics and the prognosis were compared. [Results]①The positive expression of VEGF-C and IGF-1R were 61. 76% and 55.88% respectively in pancreatic carcinoma tissue. The positive rate of VEGF-C and IGF-1R were significantly higher in pancreatic carcinoma than those in pancreatic normal tissue（20 % and 10% ） （ P 〈0.05）.②The positive expression of VEGF-C and IGF-1R（79.16 % and 70.83%）were significantly higher in group of lymph node metastasis than those in group without lymph node metastasis （ P〈0.05）, and the positive rate of VEGF-C and IGF-1R were higher in UICC grade Ⅲ and IV than in I and Ⅱ. ③Close correlation was found between VEGF-C and iGF-1R （ P〈0.05）. ④Proeessed through the kaplan-meir method, the survival rate of VEGF-C and IGF-1R expression positive group was less than that of negative group. [Conclusion]Positive expression of VEGF-C and IGF-1R is increased in the pancreatic carcinoma, and their positive rate is closely correlated with each other. The detection of the VEGF-C expression combined with IGF-1R expression might be helpful to judge lymphatic metastasis and pathogenetic condition, and to predict the prognosis of pancreatic carcinoma.