凝血、甘油三酯水平预测早发型重度子痫前期孕妇分娩结局的分析

目的 观察凝血、甘油三醋(triglyceride,TG)在早发型重度子痫前期(early onset severe pre-eclampsia,EOSP)孕妇中的表达水平,并分析凝血、TG水平预测EOSP孕妇分娩结局的价值.方法 回顾性分析2019年1月至2020年12月于邯郸市中心医院产检并完成分娩的55例EOSP...

Analysis of blood coagulation and triglyceride levels in predicting delivery outcome of pregnant women with early onset severe pre-eclampsia

Objective To observe the expression of blood coagulation and triglyceride(TG) in pregnant women with early onset severe pre-eclampsia(EOSP),and to analyze the value of blood coagulation and TG levels in predicting the delivery outcome of pregnant women with EOSP.Methods The clinical data of 55 EOSP pregnant women with adverse delivery outcomes who underwent prenatal examination and completed delivery in Handan Central Hospital from January 2019 to December 2020 were retrospectively analyzed, and set as the adverse group;in addition, the clinical data of 55 EOSP pregnant women with good delivery outcomes who underwent prenatal examination and completed delivery in our hospital during the same period were collected, and set as the good group;the medical records of pregnant women were collected, the baseline data, four coagulation items prothrombin time(PT),thrombin time(TT),fibrinogen(FIB),activated partial thromboplastin time(APTT)] and TG levels were recorded, and the value of coagulation and TG levels in predicting the risk of adverse delivery outcomes of pregnant women with EOSP was analyzed.Results There were no significant differences in age, gestational age at delivery, maternal type, body mass index and TT level between the two groups(P>0.05);the levels of PT,APTT and high density lipoprotein cholesterol(HDL-C) in the adverse group were lower than those in the good group, and the levels of FIB,TG,total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) in the adverse group were higher than those in the good group(P<0.05);Correlation test showed that the delivery outcome of pregnant women with EOSP was negatively correlated with PT,APTT and HDL-C levels(r<0,P<0.05),it was positively correlated with FIB,TG,TC and LDL-C(r>0,P<0.05),there was no correlation with TT level(P>0.05);the ROC curve was drawn, the AUC of low expression of serum PT and APTT,over expression of serum TG and FIB in predicting the risk of adverse delivery outcomes of pregnant women with EOSP were >0.80,which had certain predictive value, when the cut-off values of the four factors were 10.13 s, 23.47 s and 2.64 mmol/L,4.54 g/L respectively, the best predictive value could be obtained.Conclusion Coagulation and TG are related to the delivery outcome of pregnant women with EOSP,the low expression of PT and APTT,the over expression of TG and FIB have certain value in predicting the risk of adverse delivery outcome of pregnant women with EOSP,early monitoring of coagulation and TG indexes of pregnant women with EOSP can be considered, which can guide the prediction of risk of adverse delivery outcomes.