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| 尿激酶型纤溶酶原激活物受体及可溶性尿激酶型纤溶酶原激活物受体与炎症相关的研究进展 | |
| 引用本文： | 刘揆亮,吴静. 尿激酶型纤溶酶原激活物受体及可溶性尿激酶型纤溶酶原激活物受体与炎症相关的研究进展[J]. 国际病理科学与临床杂志, 2014, 0(4): 425-430 |
| 作者姓名： | 刘揆亮 吴静 |
| 作者单位： | 首都医科大学附属北京世纪坛医院消化内科,北京100038 |
| 基金项目： | 北京市卫生系统高层次卫生技术八才培养计划基金（2011-RCl）. |
| 摘 要： | 尿激酶型纤溶酶原激活物受体（urokinase plasminogen activator receptor,uPAR）与尿激酶型纤溶酶原激活物（urokinase plasminogen activator,uPA）同为纤溶酶原激活系统的主要成员,是一种协调多种信号转导途径的多功能分子,可溶性尿激酶型纤溶酶原激活物受体（soluble urokinase plasminogen activator receptor,suPAR）是其可溶形式。除凝血-纤溶以外,uPAR参与了肿瘤侵袭及炎症等多种疾病过程,而suPAR可能是一种良好的炎性标志物。本文就uPAR及suPAR在炎症中的作用进行简要综述。 |
| 关 键 词： | 尿激酶型纤溶酶原激活物受体 可溶性尿激酶型纤溶酶原激活物受体 炎症 |
Recent advances of urokinase plasminogen activator receptor and soluble urokinase plasminogen activator receptor in inflammation |
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| LIU Kuiliang,WU Jing. Recent advances of urokinase plasminogen activator receptor and soluble urokinase plasminogen activator receptor in inflammation[J]. Journal of International Pathology and Clinical Medicine, 2014, 0(4): 425-430 | |
| Authors: | LIU Kuiliang WU Jing |
| Affiliation: | (Department of Gastroenterology, Beijing Shijita n Hospital, Capital Medical University, Beijing 100038, China) |
| Abstract: | Urokinase plasminogen activator receptor （uPAR） and uroldnase plasminogen activator （uPA） are both members of plasminogen activator system, uPAR is a multifunctional molecule in orchestrating multiple signal processes, and suPAR is the soluble form of uPAR. Besides coagulation and fibrinolysis, uPAR is also involved in other pathological processes, such as cancer and inflammation, suPAR is suggested as a potent inflammatory marker. We briefly reviewed recent advances about the role of uPAR and suPAR in inflammation in this article |
| Keywords: | urokinase plasminogen activator receptor soluble urokinase plasminogen activator receptor inflammation |
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