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| 原发性开角型青光眼患者血清 miR-29b 差异性表达 | |
| 引用本文： | 翟玉喜,高建鲁. 原发性开角型青光眼患者血清 miR-29b 差异性表达[J]. 山东医大基础医学院学报, 2013, 0(6): 79-81 |
| 作者姓名： | 翟玉喜 高建鲁 |
| 作者单位： | 聊城市人民医院泰山医学院聊城临床学院眼科,山东聊城252000 |
| 基金项目： | 山东省自然科学基金（ZR2012HM019） |
| 摘 要： | 目的检测散发原发性开角型青光眼（POAG）患者血清miR-29b表达，探讨miR-29b在分子水平致病机制中的作用。方法通过qRT—PCR技术检测并比较20例散发POAG患者及20例健康对照者血清miR-29b表达的差异性。结果散发POAG组血清miR-29b相对表达量是健康对照组的0．15倍，差异有统计学意义（P=0．03）。结论散发POAG组血清miR-29b表达较健康对照组明显下调，提示miR-29b在POAG致病机制中可能起重要作用。 |
| 关 键 词： | 原发性开角型青光眼 细胞外基质 miR-29b |
Different expression of miR-29b in serum of primary open-angle glaucoma patients. |
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| ZHAI Yu-xi,GAO Jian-lu. Different expression of miR-29b in serum of primary open-angle glaucoma patients.[J]. Journal of Preclinical Medicine College of Shandong Medical University, 2013, 0(6): 79-81 | |
| Authors: | ZHAI Yu-xi GAO Jian-lu |
| Affiliation: | . Department of Ophthalmology, Liaocheng Clinical School, Taishan Medical College, Liaocheng People＇s Hospital, Liaocheng 252000, Shandong, China |
| Abstract: | Objective To test the expression of miR-29b in primary open-angle glaucoma（POAG） patients＇ serum and discuss its function in the pathogenesis of POAG. Methods qRT-PCR was used to detect the expression of miR-29b both in 20 sporadic POAG patients and 20 healthy people. The results were compared. Results The expression of miR-29b in sporadic POAG patients was 0.15 times the value of healthy group. The difference was statistically signifi- cant（P = 0.03）. Conclusion The expression of miR-29b in sporadic POAG patients＇ serum was significantly down- regulated, which indicated that miR-29b may play an important role in the pathogenesis of POAG. |
| Keywords: | Primary open-angle glaucoma Extracellular matrix MicroRNA-29b |
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