依诺沙星对大鼠茶碱药代动力学的影响

为探讨国产依诺沙星（ＥＮＸ）大鼠血浆茶碱（ＴＰ）药动学的影响，给临床合理使用提供实验依据。经灌胃给予大鼠单剂量ＴＰ２０ｍｇ／ｋｇ，同时给予ＥＮＸ（３００ｍｇ／ｋｇ）３次，用ＨＰＬＣ法测定给ＴＰ后１、３、５、７、１２、２４小时的血浆ＴＰ浓度。结果显示茶碱以一室药动学模型消除，ＥＮＸ使浓度明显升高Ｔ１／２β延长，ＡＵＣ增大，血浆清除率下降，具有剂量依赖性，由此表明国产ＥＮＸ与ＴＰ有明确的相互作用，合用

Effect of enoxacin on pharmacokinetics of theophylline in rats]

In order to obtain an experimental evidence for Enoxacin(ENX) to be correctly used in clinical treatment, we studied the effect of ENX on the pharmacokinetic parameters of theophylline(TP). A single oral dose of TP 20 mg/kg was given to rats and ENX(300 mg/kg, 450 mg/kg) was co-administered orally three times to those rats. The plasma concentrations of TP were determined by HPLC after TP was administered 1, 2, 3, 5, 7, 12 and 24 hrs. The results showed that TP was eliminated by one compartment model. TP plasma concentrations and AUC were significantly increased. T1/2 beta of TP was prolonged. The total clearance of TP was decreased when compared with the control. This interaction was dose-dependent. It was concluded that the interaction between ENX and TP existed. Concomitant use of ENX with TP should be avoided.