| Abstract: | ![]()
Erythropoietin and erythropoiesis inhibitor were studied in 22 healthy neonates and 31 neonates with transposition of the major arteries (TMA) using polycythemic mice as the model. Erythropoietin could not be detected in the plasma or urine of healthy neonates aged 5–7 days, but erythropoiesis inhibitor was found during this period. The erythropoietin level was raised in neonates with TMA until the 14th day, and lowered from the 14th to the 56th day. In concentrates of the 24-hourly urine sample from neonates with hypoxia aged 3–4 weeks erythropoiesis inhibitor also was found. The role of erythropoiesis inhibitor as a physiological regulator appearing in the blood of healthy neonates and neonates with hypoxia in the normalization of erythropoiesis during the first weeks after birth is discussed.Laboratory of Pathophysiology, Central Research Institute of Hematology and Blood Transfusion, Moscow. Department of Neonatal Care, Charité Children's Hospital, Medical Department of the Humboldt University, East Berlin. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 8, pp. 156–158, August, 1978. |
