REM sleep deprivation impairs muscle regeneration in rats |
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| Authors: | Marcos Mônico-Neto Murilo Dáttilo Daniel Araki Ribeiro Kil Sun Lee Marco Túlio de Mello Sergio Tufik |
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| Affiliation: | 1. Department of Psychobiology,;2. Laboratório Interdisciplinar em Fisiologia e Exercício - LAIFE, S?o Paulo, Brazil, and;3. Department of Biosciences,;4. Department of Biochemistry, Universidade Federal de S?o Paulo, S?o Paulo, Brazil,;5. School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;6. Department of Psychobiology, |
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| Abstract: | ![]()
Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion.Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96?h (SD96), control plus sleep recovery period (CTL?+?R) and SD96h plus 96?h of sleep recovery (SD96?+?R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery.Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers.Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration. |
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| Keywords: | IGF-1 sleep loss skeletal muscle muscle recovery |
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