|
|||||
|
|
| 滋水降火饮对实验性高血压大鼠淋巴细胞AngⅡ受体mRNA表达的影响 | |
| 引用本文： | 廖圣宝,丁荣光,丁丽俐,刘光伟. 滋水降火饮对实验性高血压大鼠淋巴细胞AngⅡ受体mRNA表达的影响[J]. 中国中药杂志, 2002, 27(7): 531-534 |
| 作者姓名： | 廖圣宝 丁荣光 丁丽俐 刘光伟 |
| 作者单位： | 1. 安徽中医学院,安徽,合肥,230038 2. 中国科技大学,安徽,合肥,230038 |
| 基金项目： | 安徽省自然基金资助项目 ( 98414 12 7) |
| 摘 要： | 目的 :探讨高血压神经免疫调节的内在机制和滋水降火饮作用的可能环节。方法 :采用反转录扩增(RT-PCR)技术检测二肾一夹高血压大鼠 (2K1C-RHR)AngⅡ受体 (AT-1)mRNA在淋巴细胞的表达水平的改变及滋水降火饮的干预作用。结果 :模型对照组大鼠淋巴细胞AT-1mRNA表达明显增强 ,滋水降火饮组 (20,40 g·kg-1)对此有抑制作用。结论 :滋水降火饮降低淋巴细胞AT-1mRNA的过度表达 ,可能是其发挥神经免疫调节作用的机理所在。 |
| 关 键 词： | 滋水降火饮 AngII受体 淋巴细胞 AT-1mRNA RT-PCR |
| 文章编号： | 1001-5302(2002)07-0531-04 |
| 收稿时间： | 2001-12-19 |
| 修稿时间： | 2001-12-19 |
Effect of Zishuijianghuoyin on Expression of Lymphocyte AngII Receptor (AT-1)mRNA of Experimental Hypertension Rats |
|
| LIAO Sheng bao ;DING Rong guang ;DING Li li ;LIU Guang wei. Effect of Zishuijianghuoyin on Expression of Lymphocyte AngII Receptor (AT-1)mRNA of Experimental Hypertension Rats[J]. China Journal of Chinese Materia Medica, 2002, 27(7): 531-534 | |
| Authors: | LIAO Sheng bao DING Rong guang DING Li li LIU Guang wei |
| Affiliation: | Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui, China. |
| Abstract: | Objective: To explore the immuno-neurologic regulation of hypertension and its inherent law as well as the mechanisms of curing and systemic regulating effect of ZiShuiJiangHuoYin(ZSJHY). Method:To detect expression level of AT 1mRNA in two kidney one clamp renal hypertension rat lymphocyte cell by means of RT PCR. Result:The level of AT-1 mRNA in lymphocyte was higher in group of 2K1C RHR than that in normol group. ZSJHY (20g/kg,40g/kg) had regulating effect on this. Conclution:Depressing excessive expression of lymphocyte AT-1 mRNA may be one of the mechanisms where ZSJHY exert immunoregulation action. |
| Keywords: | Zishuijianghuoyin(ZSJHY) AngII lymphocyte AT-1 mRNA RT PCR |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |