| 铀促排药物研究Ⅱ:邻苯二酚类胺羧酰胺螯合剂的合成 |
| |
| 引用本文： | 徐美忠,谢毓元. 铀促排药物研究Ⅱ:邻苯二酚类胺羧酰胺螯合剂的合成[J]. 药学学报, 1986, 21(2): 148-151 |
| |
| 作者姓名： | 徐美忠 谢毓元 |
| |
| 作者单位： | 中国科学院上海药物研究所 |
| |
| 摘 要： | In searching for drugs against uranium intoxication a series of 2,3-dihydroxy-N, N′-dicarboxymethyl-N, N′-di (substituted phenylcarbamoylmethyl)-1, 4-benzenedimethanamine (Ⅵ) was synthesized starting with 2,3-dihydroxy-1, 4-benzenedimethanamine tetraacetic acid Their ability to enhance the elimination of uranyl nitrate from animal bodies was tested and three of them (Ⅵc, Ⅵe and Ⅵf) were found to be more effective than the reported uranium chelating agents, Tiron and phosphicine.
|
| 关 键 词： | 铀促排药物:2 3-二羟基-N N′-二羧甲基-N N′-二(取代苯胺甲酰甲基)-1 4-苯二甲胺 |
| 收稿时间： | 1985-03-20 |
Studies on uranium mobilization agents. II. Synthesis of polyaminopolycarboxylic acid amides with catechol moieties |
| |
| XU Mei-Zhong and XIE Yu-Yuan. Studies on uranium mobilization agents. II. Synthesis of polyaminopolycarboxylic acid amides with catechol moieties[J]. Acta pharmaceutica Sinica, 1986, 21(2): 148-151 |
| |
| Authors: | XU Mei-Zhong and XIE Yu-Yuan |
| |
| Abstract: | In searching for drugs against uranium intoxication a series of 2,3-dihydroxy-N, N′-dicarboxymethyl-N, N′-di (substituted phenylcarbamoylmethyl)-1, 4-benzenedimethanamine (Ⅵ) was synthesized starting with 2,3-dihydroxy-1, 4-benzenedimethanamine tetraacetic acid Their ability to enhance the elimination of uranyl nitrate from animal bodies was tested and three of them (Ⅵc, Ⅵe and Ⅵf) were found to be more effective than the reported uranium chelating agents, Tiron and phosphicine. |
| |
| Keywords: | 2, 3-dihydroxy-N, N'-dicarboxymeahyl-N, N'-di (substituted phenylcarbamoylmethyl)-1, 4-benzenedimethanamine Uranium mobilization agents |
|
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
