| Abstract: | ![]()
An immunization procedure is presented which enhances the immune respons to weakly immunogenic tumor-specific cell surface antigens by coupling new helper antigens to tumor cells. Mice were immunized with lyophilized tumor cell membranes to which helper antigen was coupled. Only animals which were so primed against the helper antigen as to induce delayed hypersensitivity showed an increased in vitro immune response. This was not found in mice which were not primed or which exhibited immediate hypersensitivity. The possibility is discussed of enhancing immune response by introducing additional helper determinants linked to the original antigens. |
