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| 光学纯羟基醚类化合物的合成和分离 | |
| 引用本文： | 高建华,文广伶,张其楷. 光学纯羟基醚类化合物的合成和分离[J]. 药学学报, 1987, 22(9): 708-710 |
| 作者姓名： | 高建华 文广伶 张其楷 |
| 作者单位： | 军事医学科学院药物毒物研究所 北京(高建华，文广伶)，军事医学科学院药物毒物研究所 北京(张其楷) |
| 摘 要： | dl-羟基醚类化合物3-奎宁环基-2’,2’,2’-苯基环戊基羟基乙基醚Ⅰ的抗胆碱作用已有报道。 |
| 关 键 词： | 抗胆碱物 光学异构体 羟基醚衍生物 |
| 收稿时间： | 1986-12-23 |
THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERS |
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| GAO Jian-Hua. WEN Guang-Ling and ZHANG Qi-Kai. THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERS[J]. Acta pharmaceutica Sinica, 1987, 22(9): 708-710 | |
| Authors: | GAO Jian-Hua. WEN Guang-Ling and ZHANG Qi-Kai |
| Affiliation: | Institute of Pharmacology and Toxicology. Academy of Military Medical Sciences. Beijing |
| Abstract: | By using optically pure R and S 3-quinuclidinols. two pairs of diastereoisomers (R-1) and (R-2), (S-1) and (S-2) were synthesized. Each pair was further separated by preparative TLC. The mobile phase was chloroform-methanol-ammonia water (8:2:0.07). There is a marked distinction among their affinities for M-cholinergic receptor in rat hrain The work is still in progress. |
| Keywords: | Anticholinergics: Optical isomers: Hydroxy ether derivatives |
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