| A STUDY OF MAST CELL-MEDIATED CYTOTOXICITY TO HEPATOMA CELL IN VITRO |
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| 引用本文： | 王先松,阮幼冰,武忠弼. A STUDY OF MAST CELL-MEDIATED CYTOTOXICITY TO HEPATOMA CELL IN VITRO[J]. 中国癌症研究, 1997, 0(1) |
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| 作者姓名： | 王先松 阮幼冰 武忠弼 |
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| 摘 要： | ThestudiesinrecelltyearshaveshowedthatthemastcellscouldsuppressthegroWthofsometllmorcells.lOurpreviousstudiesdemonstratedthatmastcellscouldinhibitthegroWthofratprimaryhepatomacells.2Atpresent,therearenotanyreportsabouttheeffectsofmastcellsonculturedhepdtomaGells.Inthispaper,theeffectsofratperitonealmastcellonhepatomacellline(CBan7919)wereobservedinvitFo.ThissubjectwassupportedbygrantfromNationalNatUralScientificFoundationofChina(No.39170335).MATERIALSANDMETHODSCellCultureRathepat…
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A STUDY OF MAST CELL-MEDIATED CYTOTOXICITY TO HEPATOMA CELL IN VITRO |
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| WangXiansong, Ruan Youbing, Wu Zhongbi. A STUDY OF MAST CELL-MEDIATED CYTOTOXICITY TO HEPATOMA CELL IN VITRO[J]. Chinese Journal of Cancer Research, 1997, 0(1) |
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| Authors: | WangXiansong Ruan Youbing Wu Zhongbi |
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| Affiliation: | Department of Ultrastructural Pathology Tough Medical University Wuhan 430030 |
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| Abstract: | The effects of mast cells (MCs) isolated from rat peritoneal cavity on rat hepatoma cell line (CBRH7919)in vitro were studied with phase contrast microscope,scanning and transmission electron microscope. The results showed that different degrees of degeneration were presented in all CBRH7919 cells and a few of them exhibited necrosis or disruption when CBRH7919 cells were cocultured with MCs for 24 h. In situ hybridization demonstrated that the expression of c-abc mRNA in CBRll7919 cells was markedly reduced by MCs.These results suggest that MCs had an antitumor effect. |
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| Keywords: | Liver neoplasms Mast cells Oncogenes |
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