| HPLC—MS／MS法测定人血浆中瑞巴派特浓度的不确定度分析 |
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| 引用本文： | 俞蕴莉,张全英,黄明,华雯妍,王蒙.HPLC—MS／MS法测定人血浆中瑞巴派特浓度的不确定度分析[J].中国医药科学,2013(22):42-45. |
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| 作者姓名： | 俞蕴莉 张全英 黄明 华雯妍 王蒙 |
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| 作者单位： | 苏州大学附属第二医院临床药理实验室; |
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| 摘 要： | 目的探讨高效液相色谱串联质谱（HPLC—MS／MS）法测定人血浆中瑞巴派特浓度的不确定度评定方法。方法用HPLC—MS／MS法测定人血浆中瑞巴派特浓度，通过对测试方法过程进行分析，确定不确定度来源，计算合成不确定度和扩展不确定度。结果血浆中瑞巴派特浓度测定的合成不确定度为4．83％，扩展不确定度为9．66％。结论本评定方法适用于HPLC—MS／MS法测定人血浆中瑞巴派特浓度的不确定度评定，确立不确定度的评定方法对于血药浓度的测定具有重要意义。
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| 关 键 词： | 瑞巴派特 高效液相色谱串联质谱法 不确定度 |
Uncertainty evaluation of rebamipide concentration in human plasma by HPLC-MS/MS |
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| YU Yunli,ZHANG Quanying,HUANG Ming,HUA Wenyan,WANG Meng.Uncertainty evaluation of rebamipide concentration in human plasma by HPLC-MS/MS[J].China Medicine and Pharmacy,2013(22):42-45. |
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| Authors: | YU Yunli ZHANG Quanying HUANG Ming HUA Wenyan WANG Meng |
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| Institution: | (Department of Clinical Pharmacology, the Second Affiliated Hospital of Soochow University, Suzhou 215004,China) |
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| Abstract: | Objective To evaluate the uncertainty of the determination of rebamipide in human plasma by HPLC- MS/MS. Methods The content of rebamipide in human plasma was determined by HPLC-MS/MS. Uncertainty sources were obtained from analysis of the whole procedure Of HPLC-MS/MS method. The combined standard uncertainty and expanded standard uncertainty were calculated. Results The combined standard uncertainty and expanded standard uncertainty of the determination of rebamipide concentration in human plasma was 4.83% and 9.66%, respectively. Conclusion The method is suitable for uncertainty evaluation of the determination of rebamipide in human plasma by HPLC-MS/MS method. The evaluation of measurement uncertainty is important to the determination of drug concentration in plasma. |
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| Keywords: | Rebamipide HPLC-MS/MS Uncertainty |
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