丹参多酚酸盐对2型糖尿病患者内皮功能的影响

目的 探讨丹参多酚酸盐对T2DM患者内皮功能的影响及临床意义. 方法 80例T2DM患者随机分为对照组和治疗组,每组各40例.对照组采用常规降糖药物治疗;治疗组在常规治疗的基础上加用丹参多酚酸盐注射液治疗14 d.分别测定治疗前后患者血中内皮素-1（ET-1）、一氧化氮（NO）和肱动脉血流介导的内皮依赖性血管舒张功能（FMD）.目的 对照组和治疗组ET-1水平均较治疗前降低[（192.7±18.5）vs（178.6±19.30）ng/L,（206.8±17.3）vs（126.7±16.8）ng/L,P＜0.05];血浆NO水平和FMD均明显升高[（53.5±10.6）vs（61.6±12.8）μmol/L,（72.6±12.9）vs（54.6±11.5）μmol/L,P＜0.05;（5.41±1.33）％vs（7.51±1.54）％,（5.37± 1.42）％ vs（9.82±1.76）％,P＜0.05];治疗组ET-1降低、NO升高和FMD改善均较对照组更为明显（P＜0.05）. 结论 丹参多酚酸盐能善T2DM患者内皮功能.

Effect of salvianolate on endothelial function in patients with type 2 diabetic mellitus

Objective To explore the effect of salvianolate on endothelial function in patients with type 2 diabetic mellitus.Methods Eighty patients with type 2 diabetic mellitus were randomized into control group （with routine medicine,n=40） and treatment group （salvianolate as add-on therapy to routine medicine,n =40）.The levels of endothelin 1 （ET-1） and nitric oxides （NO） were measured by enzyme-linked immunosorbent assay and nitrate enzyme reduction method,respectively.The flow-mediated dilation （FMD） of the brachial artery was assessed by echocardiography.Results Compared to the pretreatment,ET-1 was reduced significantly [（178.6 ± 19.30） vs （192.7 ± 18.5） ng/L,（126.7 ± 16.8） vs （206.8± 17.3） ng/L,P＜ 0.05];and plasma NO and FMD were increased obviously in two groups [（61.6 ± 12.8）vs（53.5±10.6）μmol/L,（72.6±12.9）vs（54.6±11.5）μmol/L,P＜0.05; （7.51±1.54）％ vs （5.41± 1.33） ％,（9.82± 1.76） ％ vs （5.37± 1.42） ％,P＜0.05].The treatment of salvianolate led to markedly lower ET-1 levels,as well as increased levels of NO and FMD,compared to control group[（126.7± 16.8） vs （178.6±19.3）ng/L,（72.6±12.9） vs （61.6±12.8）μmol/L,（9.82±1.76）％ vs （7.51± 1.54）％,P＜0.05].Conclusion Salvianolate can improve the endothelial function in patients with type 2 diabetes mellitus.