The incidence of Down syndrome in northern Finland with special reference to maternal age |
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| Authors: | J. Leisti L. Vahtola S.-L. Linna R. Herva S.-L. Koskela M. Vitali |
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| Affiliation: | Departments of Clinical Genetics, Oulu University Central Hospital, Oulu;Departments of Pathology, Oulu University Central Hospital, Oulu;Tahkokangas Central Institution, Oulu;Kolpene Central Institution, Rovaniemi;Kainuu Central Institution, Kajaani, Finland |
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| Abstract: | ![]()
The incidence of live-born children with Down syndrome was found to be 1.73/1000 (1:578) in northern Finland over the years 1965 to 1979. Despite a marked reduction in the proportion of older mothers, no significant change in the incidence was observed. Instead, an age-specific rise in the incidence for mothers aged 25 to 29 years could be shown during the last five-year period in years 1975 to 1979. |
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| Keywords: | Down syndrome maternal age effect nondisjunction |
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