THE ACTION OF RADIX REHMANNIAE AND
PLASTRUM TESTUDINIS ON BETA-
ADRENERGIC RECEPTOR-cAMP SYSTEM |
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Authors: | N Y Yi G P Feng Y M Yu Y Z Lin Z X Rong Z Q Xia S D Zhang Y E Hu |
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Abstract: | Mouse and rat pathological models were pro
duced by injections of thyroid hormone (T3 0r T4,
Model. I) or hydrocortisone (HC, Model II). A
single subcutaneous dose of isoproterenol (ISO)
caused plasma cAMP to peak in 5-15 min which
was significantly higher in mouse Models I and II
than in normal mice. Daily oral administration of
a decoction of two Yin tonics-Radix Rehmanniae
(RR) and Plastrum Testudinis (PT) reduced peak
cAMP in both models. 3H.DHA binding assay re
vealed significant elevations of the number of 3
adrenergic receptors in rat Models I and II. Decoc-
tion RR and PT restored the peaks to normal range.
Yang tonics Radix Aconiti praeparata (RAP) and
Cortex Cinnamomi (CC) showcd contradictory
effects on these models. It seems unlikely that the
action of the two tonics promotes the dlearance of
injected hormones, since injected hormone RIA iii
plasma showed no differences between Yin tonics
treated and untreated models. The therapeutic
effects of these two Yin tonics on "Yin deficiency"
syndrome of hyperthyroidism or hyperfunction of
the adrenal cortex is very probably related to their
actions on the O-adrenoreceptor-cAMP system as
stated. |
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Keywords: | |
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