聚乙二醇化干扰素与普通干扰素治疗慢性乙型肝炎成本-效果分析

目的对聚乙二醇化干扰素（PEG．IFN）与普通干扰素（IFN）治疗慢性乙型肝炎进行经济学评价。方法对本院门诊诊治的210例慢性乙型肝炎患者的48周诊疗经过和疗效进行统计，包括ALT复常率、HBVDNA转阴率、HBeAg转阴率及其血清学转换率、HBsAg转阴率及其血清学转换率。结果PEG-IFN与IFN均对慢性乙型肝炎有效，ALT复常率分别为70％、53．3％，HBVDNA转阴率分别为73．33％、56．67％，HBeAg转阴率分别为42．22％、37．5％，HBsAg转阴率分别为7．78％、1．67％。PEG-IFN组和IFN组的有效率分别为66．67％，50．83％。获得相同效果时，IFN组的成本明显低于PEG-IFN组。结论治疗慢性乙型肝炎48周，PEG—IFN组的有效率较1FN组高，而IFN组成本一效果比较低。

Cost-Effectiveness Analysis of Pegylated Interferon and Ordinary Interferon against Chronic Hepatitis B

Objective To carry out the economical evaluation of pegylated interferon and ordinary interferon in the treatment of chronic hepatitis B. Methods The efficacy and cost of 210 patients who were treated over 48 weeks with chronic hepatitis B in the outpatient were calculated, including their serum ALT normalization, reduction in serum HBV DNA level, HBeAg overcast rate and seroconversion, HBsAg overcast rate and seroconversion. The cost-effectiveness of pegylated interferon and ordinary interferon was calculated. Results Pegylated interferon and ordinary interferon were effective against chronic hepatitis B. ALT normalization was 70% and 53.3%, reduction in serum HBV DNA level was 73.33% and 56.67%, HBeAg overcast rate was 42.22% and 37.5%, HBsAg overcast rate was 7.78% and 1.67%, respectively. The efficiency in pegylated interferon groups and ordinary interferon groups was 66.67% and 50.83%, respectively. To get the same effect, the cost of ordinary interferon was obviously lower than pegylated interferon. Conclusion Pegylated interferon has better efficiency, but ordinary interferon has lower cost-effectiveness ratio, in 48 weeks treatment of chronic hepatitis B.