环氧合酶-2在Barrett食管及其相关疾病中的表达及意义

目的研究环氧合酶(COX)-2在Barrett食管(BE)及其相关疾病中的表达情况及其意义。方法应用免疫组化S-P法分别测定59例BE,5例食管腺癌,5例重度反流性食管炎(RE)患者,10例食管黏膜正常者组织中COX-2的表达情况。数据采用等级分组秩和检验。结果COX-2在BE中的阳性率为86.4%.在食管腺癌中为5/5例,与正常食管(3/10例)和RE(2/5例)比较差异均有统计学意义(P<0.05)。长段BE黏膜中COX-2表达(100.0%)较短段BE(80.9%)高(P<0.05)。不同类型BE (全周型、舌型和岛型)、不同程度肠化生(轻度、中度、重度)COX-2的表达差异均无统计学意义(P> 0.05)。结论COX-2在BE和腺癌组织中的表达显著增高,长段BE黏膜中COX-2的表达较短段BE为高。

The significance of cyclooxygenase-2 expression in Barrett'S esophagus

Objective To investigate the expression of cyclooxygenase ( COX)-2 in Barrett s esophagus(BE) and their clinical significance. Methods The expression of COX-2 was measured by im-rnunohistochemical staining(S-P method) in 59 patients with BE, 5 with esophageal adenocarcinoma, 5 with severe reflux esophagitis (RE) and 10 with normal esophageal epithelium. Results The rate of COX-2 expression was 86. 4% in BE and 5/5 in esophageal adenocarcinoma. It was significant higher than those in normal control (3/10) and RE(2/5) (P<0. 05). The expression of COX-2 in long segment of BE was 100%, which was significantly higher than that in short segment BE (80. 9%, P < 0.05). But the expression of COX-2 was no statistical differences between different types of BE (circumference, island, and tongue) , and different degrees of intestinal metaplasia in BE (P > 0. 05). Conclusion There were significantly increased the expression of COX-2 in BE, especially in long segment of BE and esophageal adenocarcinoma.