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瘦素与高血压血管平滑肌细胞增殖关系的研究进展
引用本文:Pradip Adhikari,吕祥威. 瘦素与高血压血管平滑肌细胞增殖关系的研究进展[J]. 华夏医学, 2014, 27(5): 137-140
作者姓名:Pradip Adhikari  吕祥威
作者单位:1. 桂林医学院,广西桂林,541004
2. 桂林医学院附属医院急诊科,广西桂林,541001
基金项目:项目基金:广西自然科学基金项目资助,广西医疗卫生适宜技术研究与开发项目资助,桂林市科学研究与技术开发计划课题资助
摘    要:
大量研究表明瘦素与心血管疾病发生与发展密切相关。高血压患者血管平滑肌细胞增殖显著异常,血管平滑肌细胞的可塑性对高血压心脏血管重塑非常重要,瘦素有促VSMC增殖的作用并促进神经内分泌因子的释放,从而促进高血压发生与发展。笔者就近年来瘦素与高血压患者血管平滑肌细胞增殖关系的研究进展做了探讨。

关 键 词:瘦素  高血压  血管平滑肌  细胞增殖

Research progress on relationship of leptin and high blood pressure vascular smooth muscle cell proliferation
PRADIP Adhikari,LV Xiang-wei. Research progress on relationship of leptin and high blood pressure vascular smooth muscle cell proliferation[J]. Acta Medicinae Sinica, 2014, 27(5): 137-140
Authors:PRADIP Adhikari  LV Xiang-wei
Affiliation:PRADIP Adhikari,LV Xiang-wei(1. Guilin Medical University, Guilin 541004, China; 2. Department of Emergency, the Affiliated Hospital of Guilin Medical University, Guilin 541001, China)
Abstract:
Many studies have shown that leptin is associated with the occurrence and development of cardiovascular diseases.Patients with high blood pressure shows that the vascular smooth muscle cell multiplies significantly abnormal.The plasticity of vascular smooth muscle cell is important to the plasticity of blood vessel of hypertension heart.Leptin may promote VSMC to multiply and relieve nerve-endocrine factors to the occurrence and development of hypertension.The author summarize the research progress on the relationship between leptin and high blood pressure in patients with vascular smooth muscle cell proliferation.
Keywords:leptin  high blood pressure  vascular smooth muscle  cell proliferation
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