健康成人血清胱抑素C与增龄关系的探讨

目的：探讨血清胱抑素C（CysC）在健康成人中的变化。方法：以随机整群抽样方式在北京15个社区抽取健康成人396例,其中男160例,女236例,年龄30岁～99岁。血清CysC用增强散射比浊法（PENIA）测定。5年后随访,复查上述检查,随访252例,男99例,女153例,年龄35岁～89岁,并用双血浆法测定肾小球滤过率（GFR）。结果：横断面分析显示老年组（≥65岁）血清CysC高于青年组（〈65岁）（P〈0.01）。10岁年龄段分层分析,50岁以下血清CysC浓度男性高于女性。纵向分析5年后血清CysC较5年前升高（P〈0.05）。CysC与年龄呈正相关（r=0.551,P〈0.01）、与GFR呈负相关（r=-0.555,P〈0.01）;多元线性回归分析发现年龄、GFR、腰臀比、总胆固醇是血清CysC的独立相关因素。结论：健康人血清CysC随年龄增加而升高,而且在30岁～50岁具有性别差异。血清CysC升高不仅仅由肾功能减退所致。腰臀比、尿酸也是血清CysC的独立相关因素。

Correlation Analysis between Serum Cystatin C and Aging in Healthy Adults

Objective：To analyze whether cystatin C is increasing with aging in Chinese healthy adults.Methods：On the basis of cluster sampling,396 healthy adults（160 males and 236 females 30～99 years in age）in Beijing were selected.Serum cystatin C was measured by particle-enhanced nephelometric immunoassay（PENIA）.Five years later,the follow-up was carried out,and the above examinations were repeatedly performed.Glomerular filtration rate was measured with two-sample method.Results：Cross-sectional analysis revealed that serum cystatin C concentration was higher in the eldly group（≥65 years）than in the young group（65 years）.Stratified by 10-year-in age analysis revealed that in subjects under 50 years old,serum cystatin C concentrations was higher in men than in women（P〈0.05）.Five-year longitudinal analysis showed that the level of serum cystatin C increased compared with that of 5 years ago.Serum cystatin C was correlated positively to age（r=0.551,P〈0.01）and negatively to GFR（r=-0.555,P〈0.01）.In multivariate analysis,independent associations with serum cystatin C were found for age,GFR,waist-hip ratio and total cholesterol.Conclusion：Serum cystatin C concentrations are to increase with aging and there are sex difference in people aged in 30～50 years.Serum cystatin C＇s increasing with aging is not merely affected by kidney function.Waist-hip ratio and uric acid ester are also independently associated with higher serum cystatin C levels.