树突状细胞Toll样受体介导的信号传导通路

树突状细胞(DC)是体内功能最强的抗原提呈细胞,是机体联系固有免疫应答和适应性免疫应答的桥梁.DC表面的Toll样受体(TLRs)在接受外界刺激信号和诱导机体产生免疫应答方面具有核心作用.TLRs介导的胞内信号传导通路主要有两条:髓样分化蛋白88(MyD88)依赖途径与MyD88非依赖途径.这两条传导通路中的大部分接头蛋白分子是一致的,但在某些关键点上又有所不同,因此决定了它们的功能既相互交叉又彼此独立.

The signalling pathways of toll-like receptors in dendritic cells

Dendritic cells(DCs)are the most efficient among the antigen-presenting cells,which are the bridges that link the innate and the adaptive immunity.The toll-like receptors(TLRs)of DCs play a central role as sensors of the simulation outside and induce innate and adaptive immune responses.Different members in the TLRs family initiate different signal transduction pathways through adaptor proteins,which make reactive cells give rise to different responses.TLRs are involved in two signal transduction pathways:the MyD88 dependent and the MyD88 independent.Most adaptor proteins in the two path ways are the same.However,either pathway contains its own critical adaptor protein in the key points.Hence,it is clear that the two signal pathways fire intertwined possess a "crosstalk" in the function.