转运通路——疟疾治疗药物新靶点

处于红内期的疟原虫为摄取营养，在红细胞产生新的转运通路。由于其转运通路具有一系列生物学特性，故既可以作为直接的药物靶点，也可以作为药物寻靶途径间接引导细胞毒药物到达细胞内的作用位点，发挥抗疟作用。研究并应用该运转通路是抗疟药的研究方向之一。

New Channels and Transporters as Anti-malaria Drug Targets

In order to get more nutrition from outside the erythrocyte,new channels were induced by malaria par-asite.These channels play an important role in physiology of the parasitized cell.They are of interest both as potential targets in their own right and as potential drug targeting routes capable of mediating the entry of cytotoxic drugs into the app-ropriate compartment of the infected cell.It is hoped that this new anti-malarial strategy will help to create a sustainable anti-malaria-drug-development portfolio for the treatment of malaria.