脑梗死患者血浆神经肽Y、降钙素基因相关肽、神经降压素、胃动素动态变化及其临床意义

观察脑梗死(CI)患者神经肽Y(NPY)、神经降压素(NT)、胃动素(MTL)、降钙素基因相关肽(CGRP)浓度变化及其临床意义。方法选择C162例，用放免法检测血浆NPY、NT、MTL与CGRP浓度。结果NPY、NT与MTL浓度显著高于对照组(P<0.0001)；于发病后24h内显著升高，7d内达高峰，8～15d开始下降，15d后仍在较高水平。NPY浓度重型与大灶组显著高于轻型(P<0.05)与小灶组(P<0.01)；发病积分≥6分组显著高于<6分组(P<0.05)；高血压组显著高于正常血压组(P<0.05)。NT与MTL浓度重型组显著高于中(P<0.05)、轻型组(P<0.01)；高血糖组显著高于正常血糖组(P

LEVEL CHANGES OFNEUROPEPTIDE Y, NEUROTENSIN, MOTILIN AND CALCITONIN GENE-RELATED PEPTIDE IN PLASMA OFPATIENTS WITH CEREBRAL INFARCTION AND THEIR CLINICAL SIGNIFICANCE

Objective:To observe level changes of neuropeptide Y(NPY),neurotensin(NT),motilin(MTL) and calcitonin gene related peptide (CGRD) in plasma of patients with cerebral infarction and their clinical significance.Methods:The levels of above indicators were measured by radioimmunoassay in 62 cases (test group) with cerebral infarction and 28 subjects as the normal control.Results:In test group,the levels of DPY,NT,and MTL increased more than those in control group(P<0.0001).They started to increase significantly during the first day,and began to decrease seven days later.The level of CGRP had a contrary change with levels of NPY,NT,and MTL.There was a significant correlation between those indicators and some complicated diseases of cerebral infarction(P<0.05). Conclusion:The level changes of DPY,NT,MTL,and CGRP in patients with cerebral infarction were most significant in 7 days,and gradually recovered to normal levels 15 days later.They may be used as laboratory markers for severity of patient's condition,bulk of cerebral infarction and some complicated diseases.