Nanomedicine for acute respiratory distress syndrome: The latest application,targeting strategy,and rational design |
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| Authors: | Qi Qiao Xiong Liu Ting Yang Kexin Cui Li Kong Conglian Yang Zhiping Zhang |
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| Affiliation: | 1. Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China;2. National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan 430030, China;3. Hubei Engineering Research Center for Novel Drug Delivery System, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air–blood barrier, leading to irreversible and substantial respiratory function damage. Patients with coronavirus disease 2019 (COVID-19) have been encountered with a high risk of ARDS, underscoring the urgency for exploiting effective therapy. However, proper medications for ARDS are still lacking due to poor pharmacokinetics, non-specific side effects, inability to surmount pulmonary barrier, and inadequate management of heterogeneity. The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery. Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy, which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treatment. Through passive, active, or physicochemical targeting, nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment, thereby showing good therapeutic activity and reduced toxicity. This article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy, highlights the strategies for targeted treatment of lung inflammation, presents the innovative drug delivery systems, and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment. |
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| Keywords: | Acute respiratory distress syndrome Nanomedicine Anti-inflammatory therapy Drug delivery Targeting strategy Acute lung injury COVID-19 Pathophysiologic feature ACE2" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" angiotensin-converting enzyme 2 AEC II" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" alveolar type II epithelial cells AM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" alveolar macrophages ARDS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" acute respiratory distress syndrome BALF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" bronchoalveolar lavage fluid BSA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" bovine serum albumin CD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" 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},{" #name" :" keyword" ," $" :{" id" :" kwrd0685" }," $$" :[{" #name" :" text" ," _" :" triphenylphosphonium cation YSA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0695" }," $$" :[{" #name" :" text" ," _" :" YSAYPDSVPMMS |
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