Apalutamide-induced severe interstitial lung disease: A report of two cases from Japan |
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| Affiliation: | 1. Department of Respiratory Medicine, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minaminachi, Kobe City, Hyogo, 650-00047, Japan;2. Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Kurashiki City, Okayama, 710-8602, Japan;3. Department of Urology, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minaminachi, Kobe City, Hyogo, 650-00047, Japan;1. Kanagawa Cardiovascular and Respiratory Center, Department of Respiratory Medicine, Tomioka-Higashi 6-16-1, Kanazawa-ku, Yokohama, 236-0051, Japan;2. University of Yamanashi Hospital, Department of Internal Medicine 2, Shimokato 1110, Chuo-shi, Yamanashi, 409-3898, Japan;1. Japanese Respiratory Society Scientific Assembly of Respiratory Care, Nichinai Building., 7F, 3-28-8, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan;2. Department of Respiratory Medicine, Kobe City Medical Center General Hospital, 2-1-1 Minatojimaminami-machi, Chuo-ku, Kobe, 650-0047, Japan;3. Department of Pulmonary Medicine, School of Medicine, International University of Health and Welfare, 852 Hatakeda, Narita City, Chiba, 286-8520, Japan;4. Department of Sleep Medicine and Respiratory Care, Division of Sleep Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan;1. Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka, 807-8555, Japan;2. Department of Microbiology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka, 807-8555, Japan;3. Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan;1. Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka 591-8555, Japan;2. Department of Pathology, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka 591-8555, Japan;3. Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka 591-8555, Japan;4. Department of Radiology, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka 591-8555, Japan;5. Department of Respiratory Medicine, Kinki Central Hospital, Itami, Osaka 664-8533, Japan |
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| Abstract: | ![]()
Apalutamide, a competitive inhibitor of the androgen receptor, is being increasingly used for the treatment of prostate cancer. There have been few reports of interstitial lung disease in clinical trials of apalutamide. However, two cases of apalutamide-induced interstitial lung disease with respiratory failure in Japanese males, who were successfully treated with high-dose corticosteroids, are presented here. These cases suggest that clinicians should be alert to the potentially life-threatening risk of pulmonary toxicity associated with apalutamide treatment. |
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| Keywords: | Apalutamide Interstitial lung disease Methylprednisolone Refractory BAL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" bronchoalveolar lavage KL-6" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" Krebs von den Lungen-6 ILD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" interstitial lung disease PMDA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" Pharmaceuticals and Medical Devices Agency SP-D" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" pulmonary surfactant protein-D |
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