肾病综合征患儿细胞免疫功能的检测及其意义

目的 探讨肾病综合征(NS)患儿细胞免疫功能的变化及其意义.方法 应用流式细胞仪检测45例NS患儿及30例健康对照组外周血T淋巴细胞亚群及自然杀伤细胞(NK)的水平.结果 NS患儿活动期CD3+、CD4+、CD4+/CD8+比值、NK[CD(16+56)]+细胞均明显低于Ns缓解期和对照组(P<0.05),缓解期CD4+细胞明显低于对照组(P<0.05).结论 NS的发病与细胞免疫功能紊乱密切相关,这为调节患儿免疫功能的相关治疗提供一定依据.

Detection and significance of cellular immune function in the children with nephrotic syndrome

Objective To study the evolution and significance of cellular immune function in the children with nephrotic syndrome. Methods The level of peripheral blood T lymphocyte, netural killer in the children with nephrotic syndrome( n = 45) and normal controls group ( n = 30 ) were detected by flow cytometry. Results The percentage of CD3+ cells, CD4+ cells, CD(+16 + 56)+ cells and the ratio of CD4+/CD8+ were significantly lower at nephrotic syndrome active stage than thee in nephrotic syndrome catabasis stage and normal controls group( P < 0.05 ), the percentage of CD3+ cells were significantly lower at nephrotic syndrome catabasis stage than that in normal control group( P < 0.05 ). Conclusion The invasion of nephrotic syndrome was related to cellular immune function.