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Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer''s disease |
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| Authors: | Harald Hampel,Trey Sunderland,Hans Ulrich Kö tter,Claudia Schneider,Stefan Johannes Teipel,Frank Padberg,Ruth Dukoff,Jim Levy,Hans-Jü rgen Mö ller |
| Affiliation: | a Department of Psychiatry, Geriatric Psychiatry Branch, Ludwig-Maximilian University Munich, School of Medicine, 80336 Munich, Germany bNational Institutes of Health, National Institute of Mental Health, Geriatric Psychiatry Branch, Bethesda, MD 20892, USA |
| Abstract: | The function of the cytokine interleukin-6 (IL-6) is augmented by soluble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology. |
| Keywords: | Alzheimer's disease Cerebrospinal fluid Interleukin-6 Soluble interleukin-6 receptor Family history ELISA |
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