微血管密度及PCNA在子宫颈鳞癌中表达的临床意义

目的研究微血管密度(MVD)和增殖细胞核抗原(PCNA)与子宫颈鳞癌生长、浸润及转移的关系。方法采用免疫组化(S～P法)及组织病理学等方法，检测32例子宫颈鳞癌组织中CD34和PCNA的表达，并计算出微血管密度(MVD)和增殖指数(PI)。结果PI、MVD与肿瘤的分化程度、FIGO临床分期有密切关系。低分化程度组和高F1GO临床分期组PI、MVD值明显高于高分化程度组、及低FIGO临床分期组(P＜0．01)；淋巴结转移组PI、MVD明显高于无淋巴结转移组(P＜0.01)，且MVD与PI密切相关。(r=0．861，P＜0．01)。结论血管形成参与了子宫颈鳞癌的形成；MVD和PCNA与子宫颈鳞癌恶性程度密切相关。

The Clinical Significance of MVD and PCNA Expression in Cervix Squamous Cell Carcinoma

Objective To study the relationship between micro-vessel density(MVD), proliferating cell nuclear antigen(PCNA) expression and clinicopathological characteristics in cervix squamous cell carcinoma. Methods PCNA and CD 34 expression in 32 cervix squamous cell carcinomas were examined by SP immunohistochemical staining. MVD and proliferation index (PI) were calculated. Results PI and MVD were significantly correlated with the differentiatial degree and FIGO stage of cervix squamous cell carcinomas, and in the low differential cancers with high FIGO stage were obviously higher than those in the high differential cancers with low FIGO stage. In addition, PI and MVD in the cancers with lymph node metastasis were significantly higher than those in the cancers without one (P<0.01). Conclusion The increase of PI and MVD may promote invasion and lymph node metastasis of cervix squamous cell carcinoma.