粤东地区人群胃癌及癌前病变与细胞毒素相关蛋白幽门螺杆菌感染的关系

目的：探讨粤东地区人群中胃癌及癌前病变与细胞毒素相关蛋白幽门螺杆菌（CagA^＋Hp）感染的关系。方法：收集160例不同胃部疾病患者的标本，采用^14G-呼气试验、快速尿素酶试验和Warthin-Starry银染法检测胃组织中的Hp，采用斑点金免疫渗滤法检测血清中抗HpCagA IgG抗体。结果：慢性浅表性胃炎、慢性萎缩性胃炎伴肠化生、不典型增生、胃癌患者的Hp感染率分别为70．0％、67．7％、73．5％、54．5％（x^2=4．32，P〉0．05）。Hp感染者中CagA^＋Hp比例有逐渐增高的趋势（53．6％、61．9％、68．0％、73．3％）（x^2=2．67，P〉0．05）。结论：Hp感染，特别是CagA^＋Hp感染在癌前病变发展过程中可能起持续作用；在癌前病变患者中检测及随访CagA^＋Hp感染者可能有利于胃癌的早期诊断。

Relationship among Infection of Helicobacter pylori Expressing Cytotoxic Associated Gene Product A and Gastric Carcinoma and Precancerous Lesions in East Guangdong Region

Objective: To study the prevalence ofHelicobacter pylori(Hp)expressing cytotoxic associated gene product A(CagA)infection and its relation to human gastric carcinoma and precancerous lesions in east Guangdong region.Me thods:14C-breath test,rapid urease test and Warthin-Starry staining were used to detect Hp.Hp CagA IgG antibody in serum was detected by dot immunogold filtration assay.Results: Among 160 patients,there were 34 of chronic superficial gastritis,31 of chronic atrophic gastritis with intestinal metaplasia,34 of dysplasia,55 of gastric carcinoma.Hp infection rates were 70.0%,67.7%,73.5%,54.5%,respectively,no significant differences were found among the above dis-eases.The percentage of CagA Hp infection were 53.6%,61.9%,68.0%,73.3%,respectively,there was an in-creasing trend among the above disease.Conclusion: Hp infection,especially CagA Hp infection may play a persistent role in the progress of human gastric precancerous lesions,detection and follow-up of CagA Hp may benefit the early di-agnosis of gastric carcinoma.