| 槲寄生属植物化学成分及药理活性研究进展 |
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| 引用本文： | 曹朵,翁志洁,李建其,杨培明,何泉泉,成亮,孔德云. 槲寄生属植物化学成分及药理活性研究进展[J]. 中草药, 2015, 46(10): 1562-1570 |
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| 作者姓名： | 曹朵 翁志洁 李建其 杨培明 何泉泉 成亮 孔德云 |
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| 作者单位： | 中国医药工业研究总院 上海医药工业研究院 创新药物与制药工艺国家重点实验室, 上海 200040;中国医药工业研究总院 上海医药工业研究院 化学制药新技术中心, 上海 200437;中国医药工业研究总院 上海医药工业研究院 化学制药新技术中心, 上海 200437;中国医药工业研究总院 上海医药工业研究院 创新药物与制药工艺国家重点实验室, 上海 200040;爱茉莉太平洋(上海)研发有限公司, 上海 201801;中国医药工业研究总院 上海医药工业研究院 创新药物与制药工艺国家重点实验室, 上海 200040;中国医药工业研究总院 上海医药工业研究院 创新药物与制药工艺国家重点实验室, 上海 200040 |
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| 摘 要： | 槲寄生属植物作为传统中药药用历史悠久,其化学成分主要为黄酮类、三萜类和苯丙素类等化合物。研究表明其具有抗肿瘤、免疫调节、降血糖、抗菌、抗衰老、抗氧化、抑制血小板聚集、抗血栓形成、改善微循环和心血管系统(降压、抗心律失常、增加冠脉流量、改善冠脉循环、增强心肌收缩力、降低心肌耗氧量)等广泛的药理活性。通过对国内外有关槲寄生属植物的文献资料进行系统的整理,对其化学成分和药理作用进行总结,为槲寄生属植物的研究、开发和利用提供参考。
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| 关 键 词： | 槲寄生 黄酮类 三萜类 苯丙素类 抗肿瘤 降血糖 抗氧化 |
| 收稿时间： | 2014-11-17 |
Research progress on chemical constituents in plants from Viscum L. and their pharmacological activities |
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| CAO Duo,WENG Zhi-jie,LI Jian-qi,YANG Pei-ming,HE Quan-quan,CHENG Liang and KONG De-yun. Research progress on chemical constituents in plants from Viscum L. and their pharmacological activities[J]. Chinese Traditional and Herbal Drugs, 2015, 46(10): 1562-1570 |
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| Authors: | CAO Duo WENG Zhi-jie LI Jian-qi YANG Pei-ming HE Quan-quan CHENG Liang KONG De-yun |
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| Affiliation: | State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China;Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, China;Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, China;State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China;Amorepacific Shanghai R & I Center, Shanghai 201801, China;State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China;State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China |
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| Abstract: | Visci Herba used as traditional Chinese materia medica has a long history. Flavonoids, triterpenoids, phenylpropanoids and so on are the main chemical constituents in Visci Herba. The study shows that Visci Herba has a wide range of pharmacological activities, such as antineoplastic, antineoplastic, hyperglycemic effect, anti-microbial, anti-aging, antioxidant, antiplatelet aggregation, anti-thrombus formation, and improving minicirculation. In this paper, through arrenging the domestic and foreign relevant literatures on Visci Herba systematacially, the chemical constituents from Visci Herba and their pharmacological activities are reviewed, which could provide the reference for the further investigation and development of this plant. |
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| Keywords: | Visci Herba flavonoids triterpenes phenylpropanoids antitumor hypoglycemic anti-oxidation |
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