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| 壳多糖对兔主动脉平滑肌细胞和内皮细胞增殖的影响 | |
| 引用本文： | 王大新,吴宗贵,周斌,姜远英,殷明. 壳多糖对兔主动脉平滑肌细胞和内皮细胞增殖的影响[J]. 第二军医大学学报, 1999, 20(12): 962-964 |
| 作者姓名： | 王大新 吴宗贵 周斌 姜远英 殷明 |
| 作者单位： | 第二军医大学长征医院心血管内科,上海,200003;第二军大学药学院药理学教研室 |
| 基金项目： | 国家自然科学基金!批准号 3 96 70 3 16 |
| 摘 要： | 目的：研究壳多糖对体外培养的兔主动脉平滑肌细胞和内皮细胞生长的影响。方法：将不同质量浓度（０．２,２,２０,２００,２０００μｇ／ｍｌ）的壳多糖溶液分别加入兔主动脉平滑肌细胞和内皮细胞培养液中,培养１２,２４,４８ｈ后用ＭＴＴ经色法测定细胞数。结果：平滑肌细胞数随着壳多糖质量浓度和作用时间的增加而减少;内皮细胞数随着其质量浓度和作用时间的增加,在一定范围内相应增加。结论：壳多糖能抑制兔主动脉平滑肌 |
| 关 键 词： | 壳多糖 平滑肌细胞 内皮细胞 |
| 文章编号： | 0258-879X(1999)12-0962-03 |
Effects of chitin on the proliferation of rabbit aortic smooth muscle and endothelial cells |
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| Wang Daxin,Wu Zonggui,Zhou Bin,Jiang Yuanying,Yin Ming. Effects of chitin on the proliferation of rabbit aortic smooth muscle and endothelial cells[J]. Former Academic Journal of Second Military Medical University, 1999, 20(12): 962-964 | |
| Authors: | Wang Daxin Wu Zonggui Zhou Bin Jiang Yuanying Yin Ming |
| Abstract: | Objective: To study the effects of chitin on cultured rabbit aortic smooth muscle cells and endothelial cells. Methods: After various concentrations of chitin were added into cultured rabbit aortic smooth muscle and endothelial cells, the survey cell number were determinated by MTT colorimetric method at 12 h, 24 h and 48 h. Results: With increase of chitin concentration and action time, the number of smooth muscle cells increased and the endothelial cells reduced. Conclusion: Chitin may inhibit rabbit aortic smooth muscle cells proliferation and promote endothelial cells growth. |
| Keywords: | chitin smooth muscle cells endothelial cells |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |