Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi

Authors:	Babu S Ganley L M Klei T R Shultz L D Rajan T V

Affiliation:	Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105, USA.

Abstract:	We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.

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