我院2010-2012年抗生素药物不良反应报告调查和分析

目的 调查分析近年来我院抗生素使用的不良反应病例,总结抗生素不良反应累及器官组织以及不良反应的抗生素种类.方法 回顾我院2010年至2012年抗生素使用患者,选取出现不良反应的患者130例,统计每年出现不良反应病例数目,观察抗生素使用不良反应的发生趋势以及抗生素不良反应累及的器官组织.结果 研究结果发现抗生素在我院使用产生的不良反应逐年呈上升趋势,由2010年20.1％增长到2012年40.1％;主要引起不良反应的药物为头孢菌素类抗生素,主要累及器官有皮肤、神经系统、心血管系统等,其中累及皮肤的副作用最多,比例达29.2％,差异有统计学意义（P＜0.05）.结论 抗生素使用需要严格遵循用药原则,禁止滥用抗生素,提倡联合用药降低不良反应与提高疗效.

Investigation and analysis on antibiotics adverse drug reaction reports in our hospital, 2010-2012

Objective To investigate and analyze the adverse reaction of antibiotic use cases in recent years, summarizing adverse reaction involving the heating organs and different kinds of antibiotics with adverse reaction in our hospital. Methods From 2010 to 2012, among patients using antibiotics, we selected 130 cases with adverse reactions, every year the number of cases showing adverse reactions was observed, using antibiotic occurrence trend and adverse reaction of antibiotics in the organs and tissues. Results The adverse reaction incidence of antibiotics was increasing year by year in our hospital, which had risen from 20.1% in 2010 to 40.1% in 2012; the main drugs causing adverse reaction was cephalosporin antibiotics, the main involving organs included the skin, nervous system and cardiovascular system, the skin involving adverse reaction was the most, occupying the proportion of 29.2%, with all statistical difference showing in all data, P 〈 0.05. Conclusion The principle of medication needs to be strictly followed during antibiotics use. Abuse of antibiotics should be prohibited, the combination therapy, which can reduce adverse reaction and improve the curative effect, should be advocated.