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Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats |
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| Authors: | Wang Deming Liu Meimei Wang Yongsheng Luo Min Wang Jiazheng Dai Changzong Yan Ping Zhang Xiongjun Wang Yan Tang Chaoke Xiao Ji |
| Affiliation: | aDepartment of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan, 421001, China;bPaediatrics Department, The Second Affiliated Hospital of University of South China, Hengyang, Hunan, 421001, China;cInstitute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, Hunan 421001, China |
| Abstract: | |
| Keywords: | Abbreviations: ALI, acute lung injury ARDS, acute respiratory distress syndrome LPS, lipopolysaccharide TNF-α, tumor necrosis factor IL-1β, interleukin-1β IL-1ra, receptor antagonists to IL-1 LXRs, liver X receptors RXR, retinoid X receptor iNOS, inducible nitric oxide synthase COX-2, cyclooxygenase-2 MMP, matrix metalloproteinase NF-κB, nuclear factor kappa beta ICAM-1, intercellular adhesion molecule-1 BALF, bronchoalveolar lavage fluid MPO, Myeloperoxidase |
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