Successful treatment of Epstein–Barr Virus-associated haemophagocytic syndrome arising after living donor liver transplantation |
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| Authors: | Mingman Zhang Chunbao Guo Lunan Yan Conglun Pu Yingcun Li Quan Kang Zhimei Ren Xianqing Jin |
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| Affiliation: | Department of Hepatobiliary Surgery, Children's hospital, Chongqing Medical University, Chongqing,;Department of Hepatobiliary Surgery, West China Hospital, Sichuan University, Chengdu, China |
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| Abstract: | A 6-year-old girl received an orthotopic liver transplant secondary to liver failure of unknown etiology. Several days after liver transplantation, she developed pancytopenia and Epstein –Barr Virus (EBV)-positive seroconvert after transplant. Taking of medical history to provide evidence of pancytopenia correlated with EBV infection after transplant. Bone-marrow biopsy was carry out to confirm haemophagocytic syndrome (HPS). Laboratory investigations, including blood routine count, microscopic blood film examination, serum ferritin concentration, and liver function tests were carried out starting from the first day of suspected HPS infection, continuing until 15 weeks post-infection. Liver transplantation followed with a combination of cyclosporin A, corticosteroids, VP-16, and supportive strategies. |
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