| 黄芩甙对大鼠主动脉条收缩的影响 |
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| 引用本文： | 黑爱连 孙倾三. 黄芩甙对大鼠主动脉条收缩的影响[J]. 首都医科大学学报, 1997, 18(2): 114-117 |
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| 作者姓名： | 黑爱连 孙倾三 |
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| 作者单位： | 首都医科大学药理学教研室 |
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| 摘 要： | 分别观察黄芩甙和维拉帕米对大鼠离体主动脉条收缩张力的影响。发现：黄芩甙和维拉帕米均可使ＮＥ、ＫＣｌ及ＣａＣｌ２所致的大鼠离体主动脉条收缩张力下降，量效反应曲线右移，最大效应降低。黄芩甙的抑制作用弱于维拉帕米。２药均显著抑制ＮＥ依赖内Ｃａ２＋性收缩与外Ｃａ２＋性收缩。提示黄芩甙具有类似维拉帕米的阻滞钙离子通道的作用。
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| 关 键 词： | 黄芩甙；维拉帕米；去甲肾上腺素；氯化钾；氯化钙；主动脉条 |
| 收稿时间： | 1996-07-19 |
Effects of Baicalin on Contraction of Rat Aortic Strips |
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| Hei Ailian,Sun Songsan. Effects of Baicalin on Contraction of Rat Aortic Strips[J]. Journal of Capital Medical University, 1997, 18(2): 114-117 |
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| Authors: | Hei Ailian Sun Songsan |
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| Affiliation: | Hei Ailian,Sun Songsan Department of Pharmacology,Capital University of Medical Sciences |
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| Abstract: | Baicalin(Bai) and verapamil(Ver) inhibited the contractions of isolated rat aortic strips evoked by norepinephrine(NE),KCl and CaCl 2. They also caused the dose response curves to shift rightward and depressed the maximal response,but Bai was less potent than Ver. Both Bai and Ver inhibited the fast contraction responses evoked by NE in Ca 2+ free medium and slow Ca 2+ dependent component on contraction. The results indicated that Bai like Ver, may be a calcium antagonist. |
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| Keywords: | baicalin verapamil norepinephrine KCl CaCl 2 aorta |
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