米非司酮配伍米索前列醇终止不同孕周中期妊娠205例临床分析

目的 探讨米非司酮配伍米索前列醇终止不同孕周中期妊娠（１２～１６周和１７～２６周）的效果及安全性。方法 将符合条件药物终止纤娠的妇女２０５例，根据孕龄分成两组，给患者服用米非司酮５０ｍｇ，１２ｈ１次，共４次，总量２００ｍｇ，第３天阴道放置米索前列醇０．６ｍｇ，每１２ｈ重复１次，最多３次。结果 两组的引产成功率分别为９８．２０％和９７．８６％，两组单次米索前列醇用药的成功率分别是８２．８８％和７９．

Clinical analysis on the effect of the compatibility of mifepristone plus misoprostol to terminate midterm gestation

Objective To explore the effect and safety of the compatibility of mifepristone with misoprostol toterminate the gestation during the period of 12 to 16 weeks and 16.1 to 26 weeks of pregnancy. Methods Divide thewhole group 205 pregnant women for termination of gestation into two groups according to their ages. Took orally 50mg mifepriston every 12 hours, a total of four times then insert 0.6 mg misoprostol deep into vagina every 12 hours, amaximum of 3 times. Results The successful rates of induced labor were 98.2 % and 97.86 % respectively for bothgroups; the rates were 82.88% and 79.78% when misoprostol was used once only, (P＞0.05). Duration of placentaldischarge was proportionate to vaginal haemorrhage. When the duration of placenta discharge lasted more than 30 min-utes, vaginal haemorrhage increased significantly, (P＞0.05 ). Conclusions Compatibility of 200 mg mifepristone(taken orally) plus misoprostol (vaginally) is an effective method to terminate gestation during the period of 12 to 26weeks, and it is also proven to be a safe and successful method for induceing labor during the period of 16. 1 to 26weeks of pregnancy. Here we suggest an immediate womb clearance once the duration of placental discharge lasting formore than 30 minutes. (Shanghai Med J, 2000,23:738-740)