中药多糖的非免疫抗肿瘤作用机制

大量药理及临床研究表明,多糖类化合物是一种免疫调节剂,它能提高机体免疫功能,用于癌症的辅助治疗。但只有多糖对瘤体的直接作用明确后,才能更好的发挥其高效、低毒的优点。本文从细胞膜的生化改变、细胞内信号传递、抗自由基、诱导肿瘤细胞凋亡、影响肿瘤细胞周期、影响瘤体细胞蛋白质及核酸的合成等非免疫抗肿瘤方面,对多糖进行了综述。

Anti- tumor mechanism of chinese native medicine polysaccharide based on nonimmunity

The massive pharmacologic and clinical research indicates polysaccharide is a kind of immunity intensifier used in assistance treatment to cancer. But only after the direct action to tumor cell is clear can the polysaccharide be used better. This article carried on the summary to the polysaccharide from those aspect such as the biochemistry change on cell membrane, the signal transmission in cell, the antioxidative activity, the apoptosis of tumor cell, the influence to cycle of tumor cell, the influence to the synthesis of the cell protein and the nucleic acid and so on.