| 一平苏对糖尿病大鼠血管反应性的影响 |
| |
| 引用本文： | 王煊,李军谦,常洁,蔡德鸿,吴平生. 一平苏对糖尿病大鼠血管反应性的影响[J]. 中华高血压杂志, 2001, 9(2): 152-153 |
| |
| 作者姓名： | 王煊 李军谦 常洁 蔡德鸿 吴平生 |
| |
| 作者单位： | 解放军155医院内一科,;解放军第一军医大学附属珠 江医院内分泌科;解放军第一军医大学附属南方医院心内科 |
| |
| 摘 要： | 目的观察一平苏(西拉普利)对糖尿病大鼠血管反应性的影响。方法建立STZ所致的糖尿病大鼠血管体外灌流模型,以八道生理记录仪检测大鼠肠系膜血管反应持续时间及灌注压的变化。结果糖尿病大鼠肠系膜血管对去甲肾上腺素的反应持续时间(9.4±3.1vs5.2±2.1,P<0.01),最高灌压显著降低(5.12±0.87vs7.81±0.92kPa,P<0.01);口服一平苏8周的糖尿病组大鼠血管反应性无明显改变。
|
| 关 键 词： | 糖尿病大鼠 肠系膜血管 灌注压 血管反应 性 一平苏 |
| 文章编号： | 1006-2866(2001)02-0152-02 |
| 修稿时间： | 2000-05-24 |
Effect of Cilazapril on Reactivity of Blood Vessels in Diabetic Rats |
| |
| WANG Xuan,Li Junqian,CHANG Jie,Cai Dehong,WU Pingsheng. Effect of Cilazapril on Reactivity of Blood Vessels in Diabetic Rats[J]. Chinese Journal of Hypertension, 2001, 9(2): 152-153 |
| |
| Authors: | WANG Xuan Li Junqian CHANG Jie Cai Dehong WU Pingsheng |
| |
| Abstract: | Objective To investigate the effect of cilazapril on reactivit y of blood vessels in diabetic rats. Methods The mesenteric vessels of streptozotocin induced diabetic rats wer e perfused with Kreb-Ringer's solution in vitro,the mesenteric vessels reactivi ty of diabetic rats was measured by physiological recorder. Results The responsive continual time to norepinephrine was delay ed signific antly(9.4±3.1 vs 5.2±2.1,P<0.01) and the highest perfusion pressu re decrease significantly in diabetic rats(5.12±0.87 vs 7.81±0.92 kPa, P<0.01); When taken cilazapril showed no difference in these indexes in diabetic animal s. |
| |
| Keywords: | reactivity of blood vessels diabetic rats cilazapril |
| 本文献已被 万方数据 等数据库收录！ |
