5-羟色胺1A受体基因多态性与精神分裂症关联性的Meta分析

目的：用Meta分析的方法综合评价人群中5-羟色胺1A（5-HT1A）受体基因多态性与精神分裂症的关联，为精神分裂症的遗传背景提供循证医学证据。方法：计算机检索PubMed、Cochorane、CNKI和万方数据库，搜集有关5-HT1A 受体基因多态性与精神分裂症关联性的全文文献。以病例组和对照组5-HT1A受体基因分布的OR及其95% CI为效应指标，在全面文献回顾的基础上对文献进行筛选、评价和数据提取。应用Rev Man5.0软件对各研究原始数据进行统计分析，包括异质性检验、合并效应量以及评估发表偏倚。结果：共有5篇文献被纳入分析，其中2篇研究rs6294位点与精神分裂症的关联性，3篇研究rs6295位点与精神分裂症的关联性。精神分裂症患者rs6294位点的基因型Meta 分析结果，合并OR=0.35,95%CI=0.12～1.08，P=0.07；rs6294位点等位基因Meta 分析结果，合并OR =0.34, 95%CI=0.11～1.03，P=0.06；精神分裂症患者rs6295 位点的基因型 Meta 分析结果，合并 OR=1.78,95%CI=0.69～4.59，P=0.23；rs6295 位点的等位基因Meta 分析结果，合并OR=1.80,95%CI=1.03～3.16，P=0.04。结论：人群中5-HT1A受体基因多态性与精神分裂症有关联。   

Meta-analysis on relationship between 5-hydroxytryptamine 1A receptor gene polymorphism and schizophrenia

Objective To evaluate the association of 5-hydroxytryptamine 1A(5-HT1A) receptor gene polymorphism and schizophrenia with Meta-analysis and provide basis for evidence-based medicine for the genetic background of schizophrenia.Methods PubMed,Cochorane,CNKI and Wanfang Database were used to search all the relevant case-control trials of full text about the relationship between 5-HT1A receptor gene polymorphism and schizophrenia.The values of OR and 95%CI were used as effect indicators.It was based on reviewing full text to search,evaluate and adopt data.Statistical analysis was performed with RevMan5.0 including the heterogeneity inspection,effect consoliating and evaluatation on publication bias.Results A total of 5 articles were included after the analysis.Two of the studies were about the association between schizophrenia and 5-HT1A receptor gene rs6294,and the other 3 about 5-HT1A receptor gene rs6295.The Meta-anaylsis results of 5-HT1A receptor gene rs6294 genotype showed OR=0.35,95%CI=0.12-1.08,P=0.07;and the allele results were OR=0.34,95%CI=0.11-1.03,P=0.06;the results of 5-HT1A receptor gene rs6295 genotype were OR=1.78,95%CI=0.69-4.59,P=0.23;and the allele results were OR=1.80,95%CI=1.03-3.16,P=0.04.Conclusion 5-HT1A receptor gene polymorphism is associated with schizophrenia.