High magnesium concentrations in the dense bodies of human blood platelets from patients with atopic dermatitis and chronic myelogenous leukemia |
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| Authors: | Kenichi Takaya Kenji Niiya Masahiko Toyoda Toru Masuda |
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| Affiliation: | (1) Department of Anatomy, Toyama Medical and Pharmaceutical University, 2630, Sugitani, 930-01 Toyama, Japan;(2) Department of Clinical Laboratory Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, 930-01 Toyama, Japan;(3) Department of Dermatology, Toyama Medical and Pharmaceutical University, 2630, Sugitani, 930-01 Toyama, Japan;(4) Department of Anesthesiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, 930-01 Toyama, Japan |
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| Abstract: | ![]()
Dense bodies of the normal human blood platelet contain high concentrations of phosphorus and calcium and very small amounts of magnesium, 69 mM/kg dry weight. Quantitative energy dispersive X-ray microanalysis of the platelet dense bodies on fresh air-dried smears of blood from patients with atopic dermatitis and chronic myelogenous leukemia disclosed higher concentrations of magnesium, 251 and 176 mM/kg, respectively, as well as large amounts of phosphorus and calcium. High magnesium content in the dense bodies is discussed in relation to large amounts of magnesium in the dense bodies from the blood of rats, mice and guinea pigs. |
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| Keywords: | Human platelets X-ray microanalysis Dense bodies Magnesium Atopic dermatitis |
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