Effects of transforming growth factor beta 1 on the plasminogen activation system,collagen and integrin synthesis,and proliferation of rabbit mandibular condylar chondrocytes |
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| Institution: | 1. Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane, Japan;2. Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;1. Department of Maxillofacial Surgery and Stomatology, University Hospital Amiens, France;2. Department of Prenatal Diagnosis, Gynaecology and Obstetrics, University Hospital Amiens, France;3. Department of Medical Genetics, Rare Disease Centre, University Hospital Amiens, France;4. Department of Anatomopathology, University Hospital Amiens, France;1. Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA;2. Department of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA;1. School of Allied Health Sciences, Kitasato University, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan;2. Graduate School of Medical Sciences, Kitasato University, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan;3. Department of Radiology, Keio University, School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo 160-8582, Japan;4. Department of Radiology, Tokyo Medical Center, National Hospital Organization, Higashigaoka 2-5-1, Meguro-ku, Tokyo 152-8902, Japan;5. Kanagawa Industrial Technology Center (KITC), Shimoimaizumi 705-1, Ebina-shi, Kanagawa 243-0435, Japan;6. Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan;1. School of Stomatology, China Medical University, Shenyang, People''s Republic of China;2. Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, Tianjin, People''s Republic of China;3. Department of Head and Neck Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People''s Republic of China |
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| Abstract: | The objective of this study was to identify the mechanism by which mandibular condyle chondrocytes regulate the extracellular matrix. Primary rabbit condylar chondrocytes were isolated, cultured, and treated with transforming growth factor beta 1 (TGF-β1). Cells were then assayed for the following: urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1), collagen types I and II, β1 integrin expression, and proliferative activity. TGF-β1 induced synthesis of collagen type II, αVβ1 integrin, and PAI-1. TGF-β1 induced the growth of chondrocytes and suppressed the synthesis of uPA. Chondrocyte regulation of the extracellular matrix is mediated by TGF-β1. Synthesis of collagen type II, αVβ1 integrin, and PAI-1 is induced, while uPA is suppressed. Also, TGF-β1 induces cellular growth. |
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| Keywords: | mandibular condyle TGF-β1 extracellular matrix |
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