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Pertactin-negative variants of Bordetella pertussis in New York State: A retrospective analysis, 2004–2013
Institution:1. Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201-2002, United States;2. Emerging Infections Program, New York State Department of Health, Albany, NY 12237, United States;1. Alere Technologies GmbH, Jena, Germany;2. Institute for Medical Microbiology and Hygiene, Technical University of Dresden, Dresden, Germany;3. Department of Microbiology and Infectious Diseases, PathWest Laboratory Medicine – WA, Royal Perth Hospital, Perth, Western Australia, Australia;4. Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS), Typing and Research, School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australia;1. Department of Infectious Diseases, Section of Clinical Virology, Institute of Biomedicine, University of Gothenburg, Gothenburg 41346, Sweden;1. School of Computer Science and Information Technology, Northeast Normal University, Key Laboratory of Intelligent Information Processing of Jilin Universities, Changchun 130117, China;2. School of Mathematics and Statistics, Northeast Normal University, Changchun 130024, China;3. Key Laboratory for Applied Statistics of MOE, Northeast Normal University, Changchun 130024, China;1. Bioresource Collection and Research Center, Food Industry Research and Development Institute, 331 Shih-Pin Road, Hsinchu 30062, Taiwan;2. National Health Research Institutes, Institute of Biotechnology and Pharmaceutical Research, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
Abstract:The first report of pertactin-negative variants of Bordetella pertussis in the United States has raised questions about the role of acellular pertussis vaccines in the recent increase of pertussis cases. Our laboratory utilized a sequence-based method to identify mutations in the pertactin gene responsible for these variants and assessed vaccination status from the associated cases.
Keywords:Pertactin-negative variants  Acellular vaccine
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