Prevalence and factors associated with polypharmacy in Victorian adults with intellectual disability |
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| Affiliation: | 1. Health Intelligence Unit, Victorian Government Department of Health, 50 Lonsdale Street, Melbourne, Victoria 3000, Australia;2. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia;3. Service Design and Implementation Group, Victorian Government Department of Human Services, 50 Lonsdale Street, Melbourne, Victoria 3000, Australia;4. Centre for Disability Research & Policy, University of Sydney, Australia;1. Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Campus Heymans, Ghent University Hospital, 2B3, De Pintelaan 185, B-9000 Ghent, Belgium;2. Centre of Human Genetics, University Hospitals Leuven, & Department of Human Genetics, KU Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium;3. Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, B-9000 Ghent, Belgium;4. Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, B-9000 Ghent, Belgium;5. Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium;1. Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, 401 Quarry Road, Stanford, CA 94305, United States;2. Department of Radiology, Stanford University, School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, United States;3. Department of Pediatrics, Stanford University, School of Medicine, 300 Pasteur Drive, Stanford CA 94305, United States;1. Department of Physical Medicine and Rehabilitation, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan;2. Department of Senior Citizen Service Management, Chia Nan University of Pharmacy & Science, Tainan, Taiwan;3. Department of Business Administration and Language Education Center, Chang Jung Christian University, Tainan, Taiwan;4. Department of Otolaryngology, National Cheng Kung University Hospital, Tainan, Taiwan;5. Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan;6. Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan;1. Department of Special Education and Counselling, The Hong Kong Institute of Education, Hong Kong;2. Department of Psychology, The University of Hong Kong, Hong Kong;1. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Melbourne, Victoria, Australia;2. Discipline of Psychology, Victoria University, Melbourne, Australia;3. College of Sport and Exercise Science & Institute of Sport Exercise and Active Living, Victoria University, Melbourne, Victoria, Australia |
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| Abstract: | ![]()
Although polypharmacy is a medication safety concern leading to increased risk of non-adherence, adverse drug reaction and drug–drug interactions, polypharmacy and associated risk factors has rarely been investigated involving people with ID at a population level. The purpose of this paper is to analyze the prevalence of polypharmacy and to evaluate the role of different factors associated with polypharmacy in a state-wide representative population of adults with ID. In a population-based survey in Victoria, Australia, 897 people with ID 18 years of age or older were selected by simple random sampling. The data were collected from proxy respondents on behalf of people with ID. Polypharmacy was defined as the concomitant use of five or more medications. The data were weighted to reflect the age/sex/geographic distribution of the population. Results revealed that more than 76% of adults with ID had used prescribed medicine and about 21% were exposed to polypharmacy in the last two weeks. In both univariate and multivariate analyses, polypharmacy was significantly associated with older age, unemployment and inability to get help from family and friends if needed. After controlling for age, sex and severity of intellectual disability, polypharmacy was associated with having a blood pressure, blood cholesterol and blood glucose level check. Polypharmacy was also associated with a greater number of visits to general practitioners, fair or poor reported health status and inability to walk unaided. Subjects with epilepsy, diabetes, stroke, osteoporosis and cancer had a higher probability of polypharmacy. None of the disease inducing behaviors was associated with polypharmacy. This study highlights the need that medication should be regularly reviewed overall in ID population and particularly when polypharmacy exists. |
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| Keywords: | Intellectual disability Developmental disability Pharmacoepidemiology Medicine use Polypharmacy |
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