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Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex
Affiliation:1. Biotechnological and Applied Clinical Sciences Department, University of L’Aquila, Via Vetoio – Coppito 2, 67100 L’Aquila, Italy;2. Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy;1. Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia;2. Centre for Neural Engineering, The University of Melbourne, Parkville, Melbourne, Australia;3. Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Melbourne, Australia;1. Psychiatry, Brighton and Sussex Medical School, University of Sussex, United Kingdom;2. Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, United Kingdom;3. Department of Neuropsychiatry, Institute of Neurology, University College London, United Kingdom;1. Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, NY, USA;2. Department of Neurosurgery, Gates Vascular Institute, Kaleida Health, Buffalo, NY, USA;3. Cerebrovascular Neurosurgery, PeaceHealth Sacred Heart Medical Center, 333 Riverbend Drive, Springfield, OR 97477, USA;4. Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA;5. Department of Radiology, University at Buffalo, State University of New York, Buffalo, NY, USA;6. School of Medicine and Biomedical Sciences, Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, NY, USA;7. Jacobs Institute, Buffalo, NY, USA;1. Child Neurology Unit & Epilepsy Service, Meyer Children Hospital, Rambam Health Care Campus, Haifa, Israel;2. Molecular Pharmacology Department and Oral Biochemistry Laboratory, Israel;3. Rappaport Faculty of Medicine, Technion – Israel Institute of Technology Haifa, Israel;1. Saul R. Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, Bronx, NY, USA;2. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA;3. Einstein/Montefiore Comprehensive Epilepsy Center, Albert Einstein College of Medicine, Bronx, NY, USA;4. Department of Statistics, Albert Einstein College of Medicine, Bronx, NY, USA;5. Unité de Neurologie et Neuroréhabilitation Pédiatrique, Département Médico-Chirurgical de Pédiatrie, CHUV, Lausanne, Switzerland;6. NeuroAdjuvants, Inc., Salt Lake City, UT, USA;7. Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA
Abstract:
Keywords:Seizure  Muscarinic receptor  Nitric oxide  Phosphoinositide hydrolysis  Pilocarpine  Kainic acid
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