Abstract: | After preliminary administration of -methyldopa to mice, the stereotypes induced by L-dopa were potentiated and prolonged. The ability of L-dopa to abolish catalepsy induced by reserpine and haloperidol also was potentiated. In cats, -methyldopa potentiated the responses of the arterial blood pressure and contractions of the nictitating membrane induced by L-dopa and dopamine, if the interval between injection of the substances was 4–6 h.Department of Pharmacology, Faculties of Internal Medicine and Preventive Medicine, I. M. Sechenov First Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 3, pp. 314–316, March, 1976. |