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| 口腔颌面部肉瘤微血管密度及VEGF和bFGF的表达 | |
| 引用本文： | 王彦敏,张杰英,董福生,安志毅. 口腔颌面部肉瘤微血管密度及VEGF和bFGF的表达[J]. 实用口腔医学杂志, 2010, 26(2). DOI: 10.3969/j.issn.1001-3733.2010.02.019 |
| 作者姓名： | 王彦敏 张杰英 董福生 安志毅 |
| 作者单位： | 1. 石家庄第三医院口腔科,050011 2. 河北医科大学附属第二医院病理科 3. 河北医科大学口腔医院 |
| 摘 要： | 目的:探讨血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)与微血管密度(MVD)在口腔颌面部肉瘤的表达及与相互关系.方法: 对经病理证实口腔颌面部肉瘤57 例切片,采用免疫组化SP法检测VEGF、bFGF、MVD在瘤组织中的表达,对其相互间关系进统计学分析.结果: VEGF、 bFGF阳性率分别为82.4%、 80.7%, MVD中位数为36.24±20.48,三者明显差异于良性病变(P<0.05).VEGF、 bFGF表达和 MVD相关(P<0.05).结论: MVD、 bFGF和VEGF三者检测结果对深入探讨肉瘤血行转移形成有参考价值. |
| 关 键 词： | 口腔颌面部肉瘤 血管内皮生长因子 碱性成纤维细胞生长因子 微血管密度 免疫组化 |
A study on microvessel density,VEGF and bFGF in oromaxillofacial sarcoma |
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| WANG Yanmin,ZHANG Jieying,DONG Fusheng,AN Zhiyi. A study on microvessel density,VEGF and bFGF in oromaxillofacial sarcoma[J]. Journal of Practical Stomatology, 2010, 26(2). DOI: 10.3969/j.issn.1001-3733.2010.02.019 | |
| Authors: | WANG Yanmin ZHANG Jieying DONG Fusheng AN Zhiyi |
| Affiliation: | WANG Yanmin1,ZHANG Jieying2,DONG Fusheng3,AN Zhiyi1.1.050011,Department of Stomatology,The Third Hospital of Shijiazhuang,China,2.Department of Pathology,The 2nd Hospital of Hebei Medical University,3.Department of Oral , Maxillofacial Surgery,School of Stomatology,Hebei Medical University,Shijiazhuang |
| Abstract: | Objective:To explore the role of MVD,bFGF and VEGF in OMFS and the relationship between them.Methods:Immunochemistry streptavidin peroxidase method was used to detect the MVD and the bFGF,VEGF expressions in 57 cases of OMFS samples.Results:MVD,bFGF and VEGF expressions were different between OMFS and benign.The close correlations were found among the expressions of VEGF,bFGF and MVD.Conclusion:The expressions of VEGF and bFGF are associated with MVD which indicated that VEGF and bFGF may play important rol... |
| Keywords: | Oromaxillofacial sarcoma Vascular endothelial growth factor Basic fibroblast growth factor Microvessel density Immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |