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| 卵巢癌化疗耐药及逆转耐药基因水平研究进展 | |
| 引用本文： | 唐琳,粱军. 卵巢癌化疗耐药及逆转耐药基因水平研究进展[J]. 国际肿瘤学杂志, 2008, 35(8): 624-626 |
| 作者姓名： | 唐琳 粱军 |
| 作者单位： | 青岛大学医学院附属医院妇科,266003 |
| 摘 要： | 卵巢癌细胞对化疗产生耐药的机制主要有肿瘤细胞内有效药物浓度降低、DNA损伤修复功能异常和细胞凋亡调控异常3个方面.逆转卵巢癌细胞耐药主要包括反义基因治疗、RNA干预、化疗药物的联合应用等. |
| 关 键 词： | 卵巢肿瘤 药物疗法 抗药性,肿瘤 基因 |
Gene study on mechanisms of chemoresistance and reversing drug- resistance in ovarian cancer |
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| Abstract: | The main mechanisms of resistance of ovarian cancer cells to chemotherapy include effective drug concentration degrading in tumor cells, dysfunction of nucleotide excision repair and abnormality of cell apoptosis regulation. The main mechanisms of reversing chemoresistance include antisense gene therapy, RNA interference, associated application of chemotherapeutics. |
| Keywords: | Ovarian neoplasms Drug therapy Drug resistance,neoplasm Genes |
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